(BOC)2NH FLUKA

(BOC)2NH FLUKA - Names and Identifiers

Name	di-tert-butyl-iminodicarboxylate
Synonyms	(BOC)2NH (BOC)2NH FLUKA N-Boc-tert-butylcarbamate N-BOC-TERT-BUTYLCARBAMATE Di-t-butyl iminodicarbonate Bis(tert-butoxycarbonyl)amine TERT-BUTYL IMINODICARBOXYLATE di-tert-butyl imidodicarbonate Bis(tert-butoxycarbonyl)ammonia Di-tert-butyl iminodicarboxylate di-tert-butyl-iminodicarboxylate Iminodicarboxylic acid di-tert-butyl ester Imidodicarbonic acid, C,C'-bis(1,1-dimethylethyl) ester Di-tert-butyl iminodicarboxylate,Ticagrelor intermediate Bis(tert-butoxycarbonyl)ammonia~N-Boc-tert-butylcarbamate
CAS	51779-32-9
EINECS	000-000-0
InChI	InChI=1/C10H19NO4/c1-9(2,3)14-7(12)11-8(13)15-10(4,5)6/h1-6H3,(H,11,12,13)
InChIKey	XCAQIUOFDMREBA-UHFFFAOYSA-N

(BOC)2NH FLUKA - Physico-chemical Properties

Molecular Formula	C10H19NO4
Molar Mass	217.26
Density	1.037±0.06 g/cm3(Predicted)
Melting Point	114-117°C(lit.)
Boling Point	273.8±9.0 °C(Predicted)
Flash Point	119.403°C
Water Solubility	Insoluble in water.
Solubility	Chloroform, Methanol
Vapor Presure	0.006mmHg at 25°C
Appearance	White to bright yellow solid
Color	White to beige
BRN	1911172
pKa	8.25±0.46(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Sensitive	Air & Light Sensitive
Refractive Index	1.442
MDL	MFCD00043309

(BOC)2NH FLUKA - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29241990
Hazard Note	Irritant

(BOC)2NH FLUKA - Reference Information

Application

Bis (tert-butoxycarbonyl) amine is a pharmaceutical intermediate, which can be prepared by one-step reaction of formamide and Boc2O. There are reports that it can be used to prepare oxadiazole derivatives that can kill microorganisms.

preparation

the solution of DMAP(0.61g,5.0mmol) in MeCN(15ml) is slowly added to the solution of formamide (2.5g,56mmol) and Boc2O(24
g,110
mol) in MeCN(15ml). After stirring at room temperature for 4h, the yellow solution was cooled to 0°C, and N,N-diethylenediamine (6.97g,60mmol) was slowly added at 0°C. The resulting mixture was stirred at room temperature for 12h and filtered through a thin silica pad; the resulting mixture was filtered at room temperature. The solvent is then evaporated under reduced pressure. The crude product was purified by silica gel chromatography and eluted with EtOAc
/hexane (1 ∶ 5) to obtain the title product, which is a white solid (10.99g,92%).

Last Update：2024-04-10 22:29:15